It is extremely rare for a vice president to run against a president he served under, and it has happened just a handful of times in U.S. history.
But Pence incurred the wrath of Trump and his supporters when, as ceremonial president of the Senate, he refused to stop the certification of Biden's victory over Trump in the 2020 election.
Trump supporters stormed the Capitol during the certification process on Jan. 6, 2021, forcing Pence, lawmakers and staff to flee to safety.
Representatives for Trump's campaign could not be immediately reached for comment on Wednesday.
Many of Trump's diehard supporters view Pence's refusal to overturn the election result as treachery, potentially complicating his path to the nomination.
Persons:
Mike Pence, Donald Trump, Pence, Joe Biden, Trump, Ron DeSantis, Pence's, Trump's, Tim Reid, Susan Heavey, Ross Colvin, Grant McCool, Angus MacSwan
Organizations:
U.S . Capitol, Republican, Democratic, Trump, Reuters, Florida, CNN, Federal, Senate, Capitol, Thomson
Locations:
America, Des Moines, Iowa, Indiana, Russia, China